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AOBPreview originally published online on March 22, 2004
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Annals of Botany 93: 483-497, 2004
© 2004 Annals of Botany Company

A Post-genomic Approach to Understanding Sphingolipid Metabolism in Arabidopsis thaliana

TERESA M. DUNN1, DANIEL V. LYNCH2, LOUISE V. MICHAELSON3 and JOHNATHAN A. NAPIER*,3

1 Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA, 2 Williams College, Williamstown, MA 01267, USA and 3 Rothamsted Research, Harpenden, Herts AL5 2JQ, UK

* For correspondence. E-mail johnathan.napier{at}bbsrc.ac.uk

Received: 28 October 2003; Returned for revision: 11 December 2003; Accepted: 6 January 2004 Published electronically: 22 March 2004

• Aims To highlight the importance of sphingolipids and their metabolites in plant biology.

• Scope The completion of the arabidopsis genome provides a platform for the identification and functional characterization of genes involved in sphingolipid biosynthesis. Using the yeast Saccharomyces cerevisiae as an experimental model, this review annotates arabidopsis open reading frames likely to be involved in sphingolipid metabolism. A number of these open reading frames have already been subject to functional characterization, though the majority still awaits investigation. Plant-specific aspects of sphingolipid biology (such as enhanced long chain base heterogeneity) are considered in the context of the emerging roles for these lipids in plant form and function.

• Conclusions Arabidopsis provides an excellent genetic and post-genomic model for the characterization of the roles of sphingolipids in higher plants.

Key words: Arabidopsis thaliana, ceramide, desaturase, lipid metabolism, long chain base, post-genomics, Saccharomyces cerevisiae, signalling, sphingolipid.


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