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AOBPreview originally published online on April 27, 2007
Annals of Botany 2007 99(6):1097-1100; doi:10.1093/aob/mcm057
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© The Author 2007. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

INVITED REVIEW

Hyperforin Accumulates in the Translucent Glands of Hypericum perforatum

Jens Soelberg1,*, Lise Bolt Jørgensen1 and Anna K. Jäger2

1 Biological Institute, Department of Evolutionary Biology, University of Copenhagen, Botanical Laboratory, Gothersgade 140, 1123 Copenhagen, Denmark
2 Department of Medicinal Chemistry, The Danish University of Pharmaceutical Science, 2 Universitetsparken, 2100 Copenhagen, Denmark

* For correspondence. E-mail jenssoelberg{at}gmail.com

Received: 22 December 2006    Returned for revision: 23 January 2007    Accepted: 9 February 2007    Published electronically: 27 April 2007

Background and Aims: Hypericum perforatum contains the therapeutically important compounds hypericin and hyperforin. Hypericin is known to accumulate in the dark glands. This investigation aimed to determine the accumulation site of hyperforin.

Methods: Dark and translucent glands as well as non-secretory tissue in leaves were manually isolated under the microscope. Hyperforin content was quantified by UV HPLC. Secretory structures were surveyed anatomically.

Key Results: The hyperforin content of intact leaves was found to be about 3 mg g–1 fresh tissue, whereas a content of about 7 mg g–1 fresh material was found in isolated translucent glands. Hyperforin was found only to occur in minute amounts in dark glands (approx. 0·4 mg g–1 fresh tissue). In non-secretory tissue no hyperforin was detected.

Conclusions: The accumulation of hyperforin detected in the translucent glands supports the proposed hypothesis that hyperforin is synthesized by the same biosynthetic machinery as monoterpenes in the chloroplasts of cells delimiting the gland.

Key words: Hyperforin accumulation, translucent gland, Hypericum perforatum


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