Annals of Botany 95/1 © Annals of Botany Company 2005; all rights reserved
The Large Genome Constraint Hypothesis: Evolution, Ecology and Phenotype
1 California Polytechnic State University, Department of Biological Sciences, San Luis Obispo, CA 93407, USA and 2 Stanford University, Department of Biological Sciences, Stanford, CA 94307, USA
* For correspondence. E-mail knight{at}calpoly.edu
Received: 22 December 2003 Returned for revision: 29 January 2004 Accepted: 18 March 2004
• Background and Aims If large genomes are truly saturated with unnecessary ‘junk’ DNA, it would seem natural that there would be costs associated with accumulation and replication of this excess DNA. Here we examine the available evidence to support this hypothesis, which we term the ‘large genome constraint’. We examine the large genome constraint at three scales: evolution, ecology, and the plant phenotype.
• Scope In evolution, we tested the hypothesis that plant lineages with large genomes are diversifying more slowly. We found that genera with large genomes are less likely to be highly specious – suggesting a large genome constraint on speciation. In ecology, we found that species with large genomes are under-represented in extreme environments – again suggesting a large genome constraint for the distribution and abundance of species. Ultimately, if these ecological and evolutionary constraints are real, the genome size effect must be expressed in the phenotype and confer selective disadvantages. Therefore, in phenotype, we review data on the physiological correlates of genome size, and present new analyses involving maximum photosynthetic rate and specific leaf area. Most notably, we found that species with large genomes have reduced maximum photosynthetic rates – again suggesting a large genome constraint on plant performance. Finally, we discuss whether these phenotypic correlations may help explain why species with large genomes are trimmed from the evolutionary tree and have restricted ecological distributions.
• Conclusion Our review tentatively supports the large genome constraint hypothesis.
Key words: Evolvability, nucleotype, genome size, ecology, evolution, phenotype
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