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AOBPreview published online on February 13, 2003
Annals of Botany, doi:10.1093/aob/mcg056
© 2003 by Annals of Botany Company
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Submitted on October 4, 2002
Revised on November 29, 2002
Accepted on December 27, 2002

Over-expression of Arabidopsis CAP Causes Decreased Cell Expansion Leading to Organ Size Reduction in Transgenic Tobacco Plants

ROBERTO A. BARRERO1, MASAAKI UMEDA1, SABURO YAMAMURA2, and HIROFUMI UCHIMIYA1*

Affiliation of the authors: 1 Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-0032, Japan; 2 Iwate Biotechnology Center, Kitakami, Iwate 024-0003, Japan

* To whom correspondence should be addressed. E-mail: uchimiya{at}iam.u-tokyo.ac.jp.

Cyclase-associated proteins (CAP) are multifunctional proteins involved in Ras-cAMP signalling and regulation of the actin cytoskeleton. It has recently been demonstrated that over-expression of AtCAP1 in transgenic arabidopsis plants causes severe morphological defects owing to loss of actin filaments. To test the generality of the function of AtCAP1 in plants, transgenic tobacco plants over-expressing an arabidopsis CAP (AtCAP1) under the regulation of a glucocorticoid-inducible promoter were produced. Over-expression of AtCAP1 in transgenic tobacco plants led to growth abnormalities, in particular a reduction in the size of leaves. Morphological alterations in leaves were the result of reduced elongation of epidermal and mesophyll cells.
Key words: Cyclase-associated proteins, AtCAP1, arabidopsis, tobacco, cell elongation.


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