Skip Navigation



AOBPreview published online on June 1, 2006
Annals of Botany, doi:10.1093/aob/mcl107
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
98/2/279    most recent
mcl107v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MILLER, G.
Right arrow Articles by MITTLER, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MILLER, G.
Right arrow Articles by MITTLER, R.
Agricola
Right arrow Articles by MILLER, G.
Right arrow Articles by MITTLER, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 21, 2005
Revised February 6, 2006
Accepted March 2, 2006

Invited Review

Could Heat Shock Transcription Factors Function as Hydrogen Peroxide Sensors in Plants?

GAD MILLER 1 and RON MITTLER 1 *

1 Department of Biochemistry and Molecular Biology, University of Nevada, Mail Stop 200, Reno, NV 89557, USA

* To whom correspondence should be addressed.
RON MITTLER, E-mail: ronm{at}unr.edu


  Abstract

• Background Heat shock transcription factors (Hsfs) are modular transcription factors encoded by a large gene family in plants. They bind to the consensus sequence ‘nGAAnnTCCn’ found in the promoters of many defence genes, and are thought to function as a highly redundant and flexible gene network that controls the response of plants to different environmental stress conditions, including biotic and abiotic stresses. Hsf proteins encoded by different genes exhibit a high degree of complexity in their interactions. They can potentially bind and activate their own promoters, as well as the promoters of other members of their gene family, and they can form homo- or heterotrimers resulting in altered nuclear localization, as well as enhanced or suppressed transcription.

• Scope In this review, we summarize recent studies on Hsf function in Arabidopsis and tomato and present evidence obtained from microarray expression studies in Arabidopsis that the Hsf gene network is highly flexible and specialized, with specific members and/or member combinations controlling the response of plants to particular stress conditions. In addition, we describe recent studies that support the hypothesis that certain Hsfs function as molecular sensors that directly sense reactive oxygen species (ROS) and control the expression of oxidative stress response genes during oxidative stress.

Keywords: Heat shock transcription factors (Hsfs), reactive oxygen species (ROS), abiotic stress, gene network, sensor.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
Y. J. Im, M. Ji, A. Lee, R. Killens, A. M. Grunden, and W. F. Boss
Expression of Pyrococcus furiosus Superoxide Reductase in Arabidopsis Enhances Heat Tolerance
Plant Physiology, October 1, 2009; 151(2): 893 - 904.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Y. Chan-Schaminet, S. K. Baniwal, D. Bublak, L. Nover, and K.-D. Scharf
Specific Interaction between Tomato HsfA1 and HsfA2 Creates Hetero-oligomeric Superactivator Complexes for Synergistic Activation of Heat Stress Gene Expression
J. Biol. Chem., July 31, 2009; 284(31): 20848 - 20857.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
L. Zhang, Y. Li, D. Xing, and C. Gao
Characterization of mitochondrial dynamics and subcellular localization of ROS reveal that HsfA2 alleviates oxidative damage caused by heat stress in Arabidopsis
J. Exp. Bot., May 1, 2009; 60(7): 2073 - 2091.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Rodriguez-Serrano, M. C. Romero-Puertas, D. M. Pazmino, P. S. Testillano, M. C. Risueno, L. A. del Rio, and L. M. Sandalio
Cellular Response of Pea Plants to Cadmium Toxicity: Cross Talk between Reactive Oxygen Species, Nitric Oxide, and Calcium
Plant Physiology, May 1, 2009; 150(1): 229 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Wrzaczek, M. Brosche, H. Kollist, and J. Kangasjarvi
Arabidopsis GRI is involved in the regulation of cell death induced by extracellular ROS
PNAS, March 31, 2009; 106(13): 5412 - 5417.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. Sugio, R. Dreos, F. Aparicio, and A. J. Maule
The Cytosolic Protein Response as a Subcomponent of the Wider Heat Shock Response in Arabidopsis
PLANT CELL, February 1, 2009; 21(2): 642 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Koussevitzky, N. Suzuki, S. Huntington, L. Armijo, W. Sha, D. Cortes, V. Shulaev, and R. Mittler
Ascorbate Peroxidase 1 Plays a Key Role in the Response of Arabidopsis thaliana to Stress Combination
J. Biol. Chem., December 5, 2008; 283(49): 34197 - 34203.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Luhua, S. Ciftci-Yilmaz, J. Harper, J. Cushman, and R. Mittler
Enhanced Tolerance to Oxidative Stress in Transgenic Arabidopsis Plants Expressing Proteins of Unknown Function
Plant Physiology, September 1, 2008; 148(1): 280 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Mol PlantHome page
D.-S. Zhang, W.-Q. Liang, Z. Yuan, N. Li, J. Shi, J. Wang, Y.-M. Liu, W.-J. Yu, and D.-B. Zhang
Tapetum Degeneration Retardation is Critical for Aliphatic Metabolism and Gene Regulation during Rice Pollen Development
Mol Plant, July 1, 2008; 1(4): 599 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
A. Nishizawa, Y. Yabuta, and S. Shigeoka
Galactinol and Raffinose Constitute a Novel Function to Protect Plants from Oxidative Damage
Plant Physiology, July 1, 2008; 147(3): 1251 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Suzuki, S. Bajad, J. Shuman, V. Shulaev, and R. Mittler
The Transcriptional Co-activator MBF1c Is a Key Regulator of Thermotolerance in Arabidopsis thaliana
J. Biol. Chem., April 4, 2008; 283(14): 9269 - 9275.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
K. Vandenbroucke, S. Robbens, K. Vandepoele, D. Inze, Y. Van de Peer, and F. Van Breusegem
Hydrogen Peroxide-Induced Gene Expression across Kingdoms: A Comparative Analysis
Mol. Biol. Evol., March 1, 2008; 25(3): 507 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
P. Kant, S. Kant, M. Gordon, R. Shaked, and S. Barak
STRESS RESPONSE SUPPRESSOR1 and STRESS RESPONSE SUPPRESSOR2, Two DEAD-Box RNA Helicases That Attenuate Arabidopsis Responses to Multiple Abiotic Stresses
Plant Physiology, November 1, 2007; 145(3): 814 - 830.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
D. Ogawa, K. Yamaguchi, and T. Nishiuchi
High-level overexpression of the Arabidopsis HsfA2 gene confers not only increased themotolerance but also salt/osmotic stress tolerance and enhanced callus growth
J. Exp. Bot., September 20, 2007; (2007) erm184v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Ciftci-Yilmaz, M. R. Morsy, L. Song, A. Coutu, B. A. Krizek, M. W. Lewis, D. Warren, J. Cushman, E. L. Connolly, and R. Mittler
The EAR-motif of the Cys2/His2-type Zinc Finger Protein Zat7 Plays a Key Role in the Defense Response of Arabidopsis to Salinity Stress
J. Biol. Chem., March 23, 2007; 282(12): 9260 - 9268.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Baniwal, K. Y. Chan, K.-D. Scharf, and L. Nover
Role of Heat Stress Transcription Factor HsfA5 as Specific Repressor of HsfA4
J. Biol. Chem., February 9, 2007; 282(6): 3605 - 3613.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Y.-y. Charng, H.-c. Liu, N.-y. Liu, W.-t. Chi, C.-n. Wang, S.-h. Chang, and T.-t. Wang
A Heat-Inducible Transcription Factor, HsfA2, Is Required for Extension of Acquired Thermotolerance in Arabidopsis
Plant Physiology, January 1, 2007; 143(1): 251 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Sakuma, K. Maruyama, F. Qin, Y. Osakabe, K. Shinozaki, and K. Yamaguchi-Shinozaki
Colloquium Paper: Dual function of an Arabidopsis transcription factor DREB2A in water-stress-responsive and heat-stress-responsive gene expression
PNAS, December 5, 2006; 103(49): 18822 - 18827.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.